Researcher awarded NIH grant to study drug-related health disparities in African-Americans

Your body's ability to effectively respond to stress may be an indicator of your vulnerability to use and abuse drugs.

A five-year, $2.5 million grant from the National Institute of Health (NIH) / National Institute of Drug Abuse (NIDA) will support research from the University of Houston College of Education to investigate mechanisms that influence drug-related health disparities in the African-American community.

Ezemenari M. Obasi, associate professor in counseling psychology and director of the Hwemudua Addictions and Health Disparities Lab (HAHDL) at UH, will lead research in Harris county and eight surrounding urban and rural counties. He says the development of drug use and abuse in the African-American community is often informed by research that rarely include African-Americans or their social and cultural experiences.

"It's a longitudinal study that will include 350 participants between the ages of 18 and 25," he said. "We'll be partnering with the community to learn how a person's social environment and related stressors can 'get-under-the-skin' and have a harmful impact on the body's regulatory system or its capacity to effectively cope with day-to-day stressors across time."

Those stressors, he says, could include exposure to violent crimes, experiences of discrimination, lack of green space, unemployment, substandard housing, substandard educational systems, pollution, high density of drug-retail outlets, and ability to pay bills and/or put food on the table.

A focal point of the research is measuring how the body reacts to environmental stressors. The body has a complex network between organs that control how we deal with stress, among other things, by regulating the production and elimination of stress-related hormones. However, chronic exposure to stressors may lead to "wear-and-tear" on this system and compromise the body's ability to effectively cope with stress. Those who have fallen into substance abuse may produce too little - or too much - of these stress-related hormones, what Obasi calls a "dysregulated human stress response."

"We are hypothesizing that people are finding ways of coping with stressors through other means as their natural human stress response begins to break down," he said. "While seemingly effective in the short-term, substance use may accelerate the breakdown and increase one's susceptibility to drug-related health disparities 20 or so years down the line."

Five cohorts (70 participants each) will be assessed and monitored for two years. While much of the research will be done in their communities and home, a great deal also will be conducted at his HAHDL.